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By Humphrey P. Rang, MB MS MA DPhil FMedSci FRS Hon FBPharmacolS, Emeritus Professor of Pharmacology, University College London, London, UK; Maureen M. Dale, MB BCh PhD, Senior Teaching Fellow, Department of Pharmacology, University of Oxford, Oxford, UK; James M. Ritter, DPhil FRCP FBPharmacolS FMedSci, Emeritus Professor of Clinical Pharmacology, King's College London, London, UK; Rod J. Flower, PhD DSc FBPharmacolS FMedSci FRS, Professor, Biochemical Pharmacology, The William Harvey Research Institute, Barts and the London, Queen Mary's School of Medicine and Dentistry, London, UK and Graeme Henderson, BSc PhD FBPharmacolS, Professor of Pharmacology, University of Bristol, Bristol, UK